Random discussion of Covid-19 not specifically related to restaurants or food

The good news of the day is that the effective transmissibility number in CA has been steadily decreasing and is now estimated as being less than 1 for almost all of the state. Here’s today’s map, where red is Re > 1, yellow is approximately Re = 0.7 - 0.9, and green is Re < 0.7.

Re Map CA

This is from the “Nowcast” on the CDPH website, CalCAT

Another good indicator is that hospitalization admissions due to covid seem to have peaked, and are expected to reach pre-omicron levels about three weeks from now:

On this plot, the peak data point is 2020. The pre-omicron level (early December) was 400. The vertical line is today’s estimated level.

Unfortunately, deaths probably won’t peak until next month.

That’s hard to reconcile with these LA Times charts showing 7-day average cases still higher than previous peaks.

Alameda County:

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LA County:

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Re > 1 means that new cases are on the rise. Values of Re below but near 1 means that new cases are more or less “stable”. But when Re is low enough, like less than 0.7 (as it is in most of CA) it just means that the number of new cases (due to reduced transmissibility) is most likely falling. Values of Re < 0.7 (roughly) don’t imply that new case numbers are low, just declining.

5 posts were split to a new topic: CNN: threat or menace

Daily SARS-CoV-2 infections and COVID-19 deaths for 177 countries and territories and 181 subnational locations were extracted from the Institute for Health Metrics and Evaluation’s modelling database. Cumulative infection rate and infection-fatality ratio (IFR) were estimated …

Most cross-country variation in cumulative infection rates could not be explained. The factors that explained the most variation in COVID-19 IFR over the same period were the age profile of the country (46·7% [18·4–67·6] of variation), GDP per capita (3·1% [0·3–8·6] of variation), and national mean BMI (1·1% [0·2–2·6] of variation). 44·4% (29·2–61·7) of cross-national variation in IFR could not be explained.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00172-6/fulltext

… note that Herby, Jonung, and Hanke themselves used the term “working paper” to describe what they had put together. Simply calling it a “Johns Hopkins study” glosses over this important distinction. A working paper is not the same as a peer-reviewed study published in a reputable scientific journal … anyone who has access to the Internet, a laptop/smartphone, and opposable thumbs, can post a “working paper” on a website.

Out of an initial batch of more than 18,590 studies, Hanke and his co-authors based their conclusions on 34 papers. They minimized or excluded papers written by epidemiologists, arguing that ones written by economists or political scientists should receive more weight because of their expertise in public policy.

“Smoking causes cancer, the earth is round, and ordering people to stay at home … decreases disease transmission. A study purporting to prove the opposite is almost certain to be fundamentally flawed,” reads a critique by the University of Oxford’s Seth Flaxman, the lead author on a 2020 study which estimated that lockdowns had likely saved up to three million lives across Europe.

I don’t know about this “John Hopkins Study”, but the original purpose of all of the restrictions, including lockdowns, was to “flatten the curve” of cases vs. time, to prevent hospital overload. Prior to the vaccines, staying in your (as in "one’s) house and avoiding any contact with others was obviously a sure way to prevent transmission. An extreme measure, but effective.

Unfortunately, pre-vaccine, people who stayed in their homes, either voluntarily or by mandate, remained susceptible to infection once they did come out of the house. Protection by sheltering in place by itself doesn’t confer permanent protection to a virus, individually or collectively. Unless everyone stays at home indefinitely, contact-free, which is ludicrous.

On the other hand, in the current vaccine phase of the pandemic if you’re fully vaccinated and boosted you (as in “one”) can come out of the house. You’ll maybe get infected, but except in cases of co-morbidities you probably won’t burden the hospitals.

The concept of lockdowns in places where vaccines are abundant and readily accessible is outdated, in other words. You and anyone you unwittingly transmit the virus to, if also fully vaccinated and boosted, can be pretty sure you won’t be contributing to the hospital problem. The curve would definitely have remained flat if everyone, or almost everyone, had done that in the US.

But of course, not even close to everyone has done that in the US. The problem in the US is an attitude issue, the asinine politicization of effective and safe vaccines, as one of the articles you posted pointed out.

Staying home often didn’t help those who lived with people who had to leave home to work, especially when work was a viral hotspot such as a meat-packing plant and/or there were a lot of people sharing a small home. Hence the demographically uneven distribution of infection in Los Angeles.

The claim that lockdowns didn’t reduce deaths was on the face of it preposterous, given how effective they were in e.g. China and Australia.

More reports of effects of long covid

Fatigue and brain fog lasting 3 - 6 months (and sometimes longer) are two of the most common post-infection covid symptoms. One factor complicating things was pointed out in a PBS article last year:

While some people who have had COVID-19 report brain fog and fatigue as lingering symptoms of their infection — what’s known as long COVID — mental health care providers around the U.S. are hearing similar complaints from people who weren’t infected by the virus.

This kind of mental fog is real and can have a few different causes. But at the root of it are the stress and trauma of the past [time period], say mental health experts. It’s a normal reaction to a very abnormal [time period].

This doesn’t dilute the issue of work absences, or the “long covid” malaise itself that’s discussed in the WKZO report, but it does make it hard to know if the symptoms were in fact directly related to covid, especially in cases of asymptomatic infections that may never have been identified.

In the US, there have been ten times as many cumulative deaths over the past two years from covid as in two typical pre-pandemic years from the flu. In China, on the other hand, the number of deaths from covid in the same two years has been, relatively, miniscule. Of course lockdowns, quarantine camps, and prohibited intermingling between actually and even potentially infected individuals, groups, cities and regions greatly reduces transmission of a readily-communicable disease like covid.

This has effectively staved off deaths from covid in China – so far. It bought them time, and by now, almost 90% of mainland Chinese are vaccinated (vs. approximately 65% fully vaccinated in the US), so if the Chinese vaccines work against omicron and are durable, the Chinese are in pretty good shape.

Over the long term, though, they may have to regularly repeat their strategy of almost unbearable, draconian-sounding lockdowns and isolation, because new covid variants aren’t going to go away. Or, if their vaccines somehow induced widespread robust T-cell protection among the population (who knows?), maybe not. Time will tell, but I wouldn’t want to have that possible scenario to look forward to.

Instead we are looking forward to the scenario of having more than 1 million covid deaths (and very likely highly underestimated) in the US soon with many more to come (and likely many more long covid cases which will have a significant impact on the health system for years to come) - not sure if this is much more desirable

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The “excess mortality” approach seems pretty solid for estimating the undercount.

Neither is desirable – “rock and a hard place”.

Prior to the vaccines, it was largely the elderly who were dying from covid in the US (and elsewhere). Many of the deaths during that period, especially in nursing homes, could have been prevented, if not all, without resorting to “home imprisonment” and quarantine camps as in China. The US didn’t act fast enough with reasonable preventative measures in the first year.

People over 65 were eligible for vaccines in January 2021 (which is when I got my first shot), and by March (I believe) they were pretty easy to get for most adults. Way too many people in the US just decided not to get them or delayed getting them for a long time. And now, the Formerly-Supreme Court says that vaccines can’t even be mandated by the federal government.

A great many of the deaths after April of last year could have been prevented in the US simply by vaccination, in other words. There’s no telling how many, exactly, but vaccine resistance was to blame for a huge number of deaths, and still is.

Vaccinations and curative medicines are the scenario that will hopefully circumvent any need for draconian lockdown measures. That’s the scenario that I envision. And for the people who choose not to get vaccinated, I have no sympathy. I just hope that the hospitals give me that bed for my heart attack rather than to some unvaccinated idiot who got seriously ill.

This seems idiotic and irresponsible to me. The only way to make sure that the unvaccinated wear masks is for everyone to wear them. And despite Omicron’s rapid decline, community spread is still almost as high as it has ever been. And the next variant to come along could be worse.

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It is.

For me, though, it’s not just about the unvaccinated wearing masks. I will be keeping my mask on indoors for at least the next few wks and still trying to keep a “decent” distance away from others outdoors…

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More interesting papers around long Covid and its implications, The second is interesting as it shows quite significant impact on heart diseases even if you didn’t have significant/hospitalized covid diseases (and raises also questions around asymptomatic cases)

https://www.nature.com/articles/s41591-022-01689-3

And one good comment on Twitter - “ The risk of major adverse cardiovascular event is 2.3% among all COVID survivors. With over 41 million covid survivors in the US, we can expect millions of cardiovascular events and almost 1 million will be major.”

And it makes the removal of mask mandates even more questionable - come for the covid infection, stay for the heart attack

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